Curiosity Shows You Useful Wikipedia Articles Right When You Need Them


Curiosity Shows You Useful Wikipedia Articles Right When You Need Them

iOS: If you’ve ever seen an interesting landmark or building and wanted to learn more about it, Curiosity is perfect for you. The app uses geolocation to float Wikipedia articles based on what’s near you, and suggests articles related to trending topics in the news, so you stay informed, too.

Curiosity’s primary source is Wikipedia, so keep that in mind while you read, but for that, it’s great at giving you the right articles when you need them. You can browse a map—centered on where you are—and see articles related to landmarks all around you. Tap one to read it, or bookmark or share it to read later. It’s ideal if you’re wandering a foreign city, or you’re just curious about what’s interesting in your own neighborhood. It’s not all factual, dry, reference stuff either—the app will show you movies filmed or set in your neighborhood, historic battles that took place nearby, and more.

If you’re curious about the news, or you see people talking about a topic on social media but don’t know the background, Curiosity can also float articles based on trending topics. If you want to try it out, it’ll set you back $2 at the iTunes App Store.

Curiosity ($2) | iTunes App Store via Curiosity by Tamper

from Lifehacker

These are some of the crazy things scientists did using gene editing in 2015


dna cut and paste crispr

Gene editing was one of the most talked-about topics of 2015, and rightly so.

One technique in particular, known as CRISPR/Cas9, has made it possible to quickly and precisely edit genes by cutting and pasting bits of DNA, opening the door to curing genetic defects and preventing the spread of disease. It’s already been used in everything from mice to human embryos.

Meanwhile, other gene editing techniques are already being developed to treat cancer and other diseases.

We compiled a list of some of the biggest advances in gene editing made this year.

Here are a few:

Modified human embryos

human embryo blastocystIn April a team of Chinese scientists made headlines when they used CRISPR in human embryos to prevent a blood disorder called beta thalessemia, which got a lot of people fired up over whether the technology should be used in humans.

In early December, a group of experts that met in Washington decided that human gene editing should not be banned completely, but should not be used on embryos until it’s proven safe.

And in late December, Congress passed a budget that makes it illegal to use federal funds to created genetically modified embryos, although some experts say this will only encourage companies to fund the research.

Pig organs for transplants

Meanwhile, scientists are also looking into how they can use gene editing to fix the shortage of organs for transplants. In October, Nature News reported that a group of Harvard scientists was using CRISPR in pig embryos to make their organs more compatible to transplant into humans.

Biologist George Church and his colleagues tweaked more than 60 genes in the pigs to get rid of harmful viruses that lurk in the animals’ DNA and could make humans sick. Church co-founded a company called eGenesis in Boston that is now trying to figure out how to make the process cheaper.

Extra-muscly dogs

crispr dogsAnd it’s not just pigs. Also in October, MIT Technology Review reported that another group of researchers in China had used CRISPR gene editing to create beagles with twice the normal amount of muscle. Specifically, the researchers edited dog embryos to cut out the myostatin gene, which keeps muscle cells from developing. When the gene was inactive, the animals could produce more muscle.

Although the first attempt was unsuccessful, the second attempt produced two dogs, a male named Hercules and a female named Tiangou (after China’s mythical "heaven dog"), with up to twice the muscle mass of their littermates.

Malaria-free mosquitoes

Gene editing isn’t only limited to curing genetic defects. It can also be used to make genetic changes spread rapidly through an entire population — something known as gene drive — to, say, prevent mosquitoes from spreading a disease.

In late November, a group of scientists at UC San Diego used CRISPR to make a population of mosquitoes resistant to spreading malaria, a disease that killed more than half a million people last year.

And just two weeks later, scientists in London announced they had modified another type of mosquito — which is responsible for 90% of malaria deaths — to stop it from spreading the disease, STAT News reported.

Unraveling the human genome

In addition to its many clinical applications, gene editing is also helping scientists understand our basic biology. In October, scientists used CRISPR to identify the set of essential genes a human cancer cell needs to survive.

These genes encode proteins involved in fundamental processes that keep our cells healthy, and are rarely mutated in nature. The findings may also guide scientists in finding a cancer’s weak points, where it is most vulnerable to attack.

CRISPR is certainly an effective way to edit a gene, but it’s not the only game in town.

A treatment for leukemia

Scientists are already using gene editing to treat diseases in people, a form of gene therapy. In November, as STAT News reported, doctors used another technique known as TALENs to treat a young girl’s leukemia, and she is now in remission. By tweaking special cells in her body’s immune system, they were able to send them on a search-and-destroy mission to target cancerous tumor cells.

Customized pet ‘micropigs’

p3In September, Nature News reported that a group of researchers at China’s genomics institute BGI was creating genetically-engineered "micropigs" to sell as pets.

They used the TALEN method gene editing to modify Bama pigs, which are already only about half as big as regular farm pigs, to inactivate a gene that controls growth. Without that gene, the pigs didn’t grow to a normal size.

The researchers plan to sell the pigs for about 10,000 yuan (US$1,600), according to Nature News.

While most of the focus on gene editing has been on human therapies, the techniques can also be used to modify plants, including the food we eat. For example, it might be possible to engineer hypo-allergenic peanuts, as MIT Technology Review reported in October.

These are just some of the creative ways scientists have used gene editing, but we can probably expect many more in the coming years.

NEXT UP: Scientists may soon be able to ‘cut and paste’ DNA to cure deadly diseases and design perfect babies

DON’T MISS: CRISPR, the gene-editing tech that’s making headlines, explained in one graphic

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NOW WATCH: Watch science writer Carl Zimmer explain CRISPR in 90 seconds

from Tech

One graph shows how the likes of Netflix and Spotify are eating the DVD and CD businesses


It won’t come as a surprise to learn that on demand streaming services are eating into DVD and CD sales.

But one chart from Goldman Sachs shows just how rapid the shifts in the entertainment industry have been over the last 15 years — first, the collapse of the rental business in the early noughties and then the rise of digital since 2007.

Here’s the chart, from Goldman’s recent round-up of its 100 best charts from the year:


The chart shows that streaming services like Netflix, Amazon Prime Video, Spotify, and Deezer now pull in almost as much revenue as physical sales and rentals of DVDs and CDs put together.

That’s a huge shift from just 7 years earlier, when digital spend was a tiny fraction of the overall total and physical sales were worth almost double their total in 2014.

Another interesting insight is that US entertainment spend seems to have peaked in 2004, before declining until 2010 when it reached a fairly stable level. Since then, digital has steadily eaten into the market share of the rental and sale market, rather than raising the spending ceiling for the market.

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NOW WATCH: Martin Shkreli may have hung up on an FBI agent live on video hours before his arrest

from Tech